Thursday, September 23, 2010

Does Herceptin prevent dimerization of the HER-2 receptor or does it freshly prevent cell signalling?

Please explain the mechanics of how Herceptin stops cancer cell growth. Not sure, I know it's a monoclonal antibody, and I pretty sure that it prevents receptor dimerization of HER-2 receptor and therefore signalling. (Wow haven't thought of Tyrosine kinase signalling for awhile.).
Here's an article
http://theoncologist.alphamedpress.org/c.
Good cross-question.

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